Spontaneous Human Adult Stem Cell Transformation

Spontaneous human adult stem cell transformation.

Human adult stem cells are being evaluated widely for various therapeutic approaches. Several recent clinical trials have reported their safety, showing them to be highly resistant to transformation. The clear similarities between stem cell and cancer stem cell genetic programs are nonetheless the basis of a recent proposal that some cancer stem cells could derive from human adult stem cells. H...

Retraction: Spontaneous human adult stem cell transformation.

thors retract the article titled “Spontaneous Human Adult Stem Cell Transtion,” which was published in the April 15, 2005, issue of Cancer Research (1). review of the data published in this article, the authors have been unable to uce some of the reported spontaneous transformation events and suspect the menon is due to a cross-contamination artifact. Five of the seven authors have to the retra...

Molecular Characterization of Spontaneous Mesenchymal Stem Cell Transformation

BACKGROUND We previously reported the in vitro spontaneous transformation of human mesenchymal stem cells (MSC) generating a population with tumorigenic potential, that we termed transformed mesenchymal cells (TMC). METHODOLOGY/PRINCIPAL FINDINGS Here we have characterized the molecular changes associated with TMC generation. Using microarrays techniques we identified a set of altered pathway...

HPV-Induced Field Cancerisation: Transformation of Adult Tissue Stem Cell Into Cancer Stem Cell

Field cancerisation was originally described as a basis for multiple head and neck squamous cell carcinoma (HNSCC) and is a pre-malignant phenomenon that is frequently attributable to oncogenic human papillomavirus (HPV) infection. Our work on β-HPV-induced cutaneous squamous cell carcinomas identified a novel Lrig1+ hair follicle junctional zone keratinocyte stem cell population as the basis f...

Low Intensity Ultrasound, Proliferation & Growth Indexes in Adult Stem Cell